Details
Disease Category
Gender
Age
57 years
Organ System/Discipline
Diagnosis
Gliosarcoma
Clinical History
57-year-old man with progressive left hemiparesis and headaches. Neuroimaging shows a large multicystic mass in the right hemisphere.
Case Discussion
Gliosarcoma is a variant of glioblastoma, a malignant glial neoplasm of the brain. Gliosarcoma is characterized by a malignant mesenchymal component in addition to areas of more typical glioblastoma. These components may resemble fibrosarcoma with long packed bundles of spindle cells or undifferentiated pleomorphic sarcoma. There may be mesenchymal differentiation with heterologous components such as bone, cartilage, muscle, etc. Staining for GFAP is usually negative while stains for collagen and reticulin are positive.
Image Contributors
Gao, A., Munoz, D.
Cite
Gao, A., Munoz, D. Brain, Gliosarcoma. Digital Laboratory Medicine Library, Dept of Laboratory Medicine & Pathobiology, University of Toronto. Published
. Accessed December 17, 2025. https://dev.dlml.cflabs.ca/image/brain-gliosarcoma-lmp93513