Details
Disease Category
Gender
Age
49 years
Organ System/Discipline
Diagnosis
IgG4-related hypophysitis
Clinical History
49-year-old man with 3-year history of hypopituitarism and diabetes insipidus. Neuroimaging shows a sellar/suprasellar mass.
Case Discussion
IgG4-related hypophysitis is a presumed autoimmune disease of the pituitary gland that can occur in isolation or in the setting of systemic IgG4-related disease. Diagnostic histopathologic criteria for IgG4-related hypophysitis are lymphoplasmacytic infiltration of the pituitary gland with more than 10 IgG4-positive cells per high power field. IgG4-related disease is typically responsive to steroids but long term patient outcomes are still lacking.
Image Contributors
Gao, A., Munoz, D.
Cite
Gao, A., Munoz, D. Brain, IgG4-related hypophysitis. Digital Laboratory Medicine Library, Dept of Laboratory Medicine & Pathobiology, University of Toronto. Published
. Accessed December 17, 2025. https://dev.dlml.cflabs.ca/image/brain-igg4-related-hypophysitis-lmp33344