Lymph Nodes, Classical Hodgkin lymphoma

Classical Hodgkin lymphoma is one of the most common cancers of young adults and adolescents. Patients present with lymphadenopathy sometimes accompanied by constitutional B symptoms (fever, night sweats and weight loss). It is characterized by the presence of neoplastic lymphocytes of B-cell origin termed Hodgkin Reed-Sternberg cells (large lymphoid cells that contain multinucleated or multilobulated nuclei with prominent viral inclusion-like nucleoli imparting an "owl eye" appearance), and variants (Hodgkin cells). The background consists of abundant mixed inflammatory cells recruited in response to cytokines produced by the tumor, often with a component of eosinophils as is seen in this example. The neoplastic cells are typically positive for CD15, CD30, and PAX-5 (weak), while negative for CD45, CD3 and CD20.