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45 year old male with enlarging parotid mass. Patient first noticed swelling 1 year ago. Ultrasound demonstrated a 2.5 cm solid nodule in superficial parotid.
Pleomorphic adenoma is the most common slow-growing, benign tumour of the salivary glands. It most frequently involves the parotid gland. This benign epithelial tumor shows both epithelial, myoepithelial elements, and mesenchymal components with myxoid, mucoid, and/or chondroid material. There is architectural diversity and mixed luminal ductal cells and luminal supporting cells. Rarely, pleomorphic adenomas can undergo malignant transformation. Tumours are positive for cytokeratin, p63, GFAP, and S100 protein.
For another example of this entity see LMP17323-Parotid gland, Pleomorphic adenoma (see link in related content).