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The placenta is that of a newborn born at 35 weeks of gestational age and admitted to NICU. The mother was 49 years old and G1P0. This was an IVF pregnancy. The baby was delivered by c-section due to abnormal fetal surveillance and oligohydramnios.
Fetal thrombotic vasculopathy (FTV) encompasses a wide variety of fetal perfusion pathologies, including those that are thromboembolic (i.e. fetal diffuse intravascular coagulopathy, true umbilical knots, maternal or fetal thrombophilia), related to fetal heart failure and/or fetal vascular wall damage. Clinically, FTV is associated with adverse pregnancy outcomes including IUGR, intrauterine fetal demise and neonatal neurologic compromise. Histologically, this condition is characterized by the presence of avascular villi with no fetal perfusion. The intervillous spaces (maternal lakes) are generally patent.
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