Uterus, leiomyosarcoma, caldesmon stain

Uterine leiomyosarcoma is a rare malignant smooth muscle tumour, representing fewer than 1% of all uterine malignancies. It is the most frequently occuring uterine mesenchymal malignancy. Uterine leiomyosarcomas exhibit aggressive growth, local recurrence, and frequent distant metastasis (commonly to lung and liver). They present as solitary large dominant masses (often greater than 10cm) with fish-flesh like consistency and indistinct bundling. Diagnosis relies on the evaluation of the coagulative tumour necrosis, mitotic activity and significant, diffuse atypia.

This slide shows caldesmon stain. See Related Content for H&E stains.