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Heavy chain diseases (HCD) are B-cell neoplasms that only produce monoclonal heavy chain without associated light chains. There are three types involving the three main immunoglobulin classes: gamma, alpha, and mu.

Gamma heavy chain disease presents like lymphoplasmacytic lymphoma in the bone marrow but lacks light chain. The slides demonstrate the presence of a neoplastic plasma cell population. Monoclonal IgG is seen by immunohistochemistry. Clinically, immunofixation will demonstrate IgG without light chain in the blood and/or urine.

This slide shows peripheral blood. See related content for bone marrow aspirate and H&E and IHC of bone marrow biopsies.

Heavy chain diseases (HCD) are B-cell neoplasms that only produce monoclonal heavy chain without associated light chains. There are three types involving the three main immunoglobulin classes: gamma, alpha, and mu.

Gamma heavy chain disease presents like lymphoplasmacytic lymphoma in the bone marrow but lacks light chain. The slides demonstrate the presence of a neoplastic plasma cell population. Monoclonal IgG is seen by immunohistochemistry. Clinically, immunofixation will demonstrate IgG without light chain in the blood and/or urine.

This slide shows bone marrow aspirate. See related content for peripheral blood, and H&E and IHC of bone marrow biopsies.

Heavy chain diseases (HCD) are B-cell neoplasms that only produce monoclonal heavy chain without associated light chains. There are three types involving the three main immunoglobulin classes: gamma, alpha, and mu.

Gamma heavy chain disease presents like lymphoplasmacytic lymphoma in the bone marrow but lacks light chain. The slides demonstrate the presence of a neoplastic plasma cell population. Monoclonal IgG is seen by immunohistochemistry. Clinically, immunofixation will demonstrate IgG without light chain in the blood and/or urine.

This slide shows bone marrow biopsy, H&E stain. See related content for peripheral blood, bone marrow aspirate, and IHC of bone marrow biopsies.

Heavy chain diseases (HCD) are B-cell neoplasms that only produce monoclonal heavy chain without associated light chains. There are three types involving the three main immunoglobulin classes: gamma, alpha, and mu.

Gamma heavy chain disease presents like lymphoplasmacytic lymphoma in the bone marrow but lacks light chain. The slides demonstrate the presence of a neoplastic plasma cell population. Monoclonal IgG is seen by immunohistochemistry. Clinically, immunofixation will demonstrate IgG without light chain in the blood and/or urine.

This slide shows bone marrow biopsy, Kappa stain. See related content for peripheral blood, bone marrow aspirate, and H&E and IHC of bone marrow biopsies.

Heavy chain diseases (HCD) are B-cell neoplasms that only produce monoclonal heavy chain without associated light chains. There are three types involving the three main immunoglobulin classes: gamma, alpha, and mu.

Gamma heavy chain disease presents like lymphoplasmacytic lymphoma in the bone marrow but lacks light chain. The slides demonstrate the presence of a neoplastic plasma cell population. Monoclonal IgG is seen by immunohistochemistry. Clinically, immunofixation will demonstrate IgG without light chain in the blood and/or urine.

This slide shows bone marrow biopsy, Lambda stain. See related content for peripheral blood, bone marrow aspirate, and H&E and IHC of bone marrow biopsies.

Heavy chain diseases (HCD) are B-cell neoplasms that only produce monoclonal heavy chain without associated light chains. There are three types involving the three main immunoglobulin classes: gamma, alpha, and mu.

Gamma heavy chain disease presents like lymphoplasmacytic lymphoma in the bone marrow but lacks light chain. The slides demonstrate the presence of a neoplastic plasma cell population. Monoclonal IgG is seen by immunohistochemistry. Clinically, immunofixation will demonstrate IgG without light chain in the blood and/or urine.

This slide shows bone marrow biopsy, CD20 stain. See related content for peripheral blood, bone marrow aspirate, and H&E and IHC of bone marrow biopsies.

Heavy chain diseases (HCD) are B-cell neoplasms that only produce monoclonal heavy chain without associated light chains. There are three types involving the three main immunoglobulin classes: gamma, alpha, and mu.

Gamma heavy chain disease presents like lymphoplasmacytic lymphoma in the bone marrow but lacks light chain. The slides demonstrate the presence of a neoplastic plasma cell population. Monoclonal IgG is seen by immunohistochemistry. Clinically, immunofixation will demonstrate IgG without light chain in the blood and/or urine.

This slide shows bone marrow biopsy, CD3 stain. See related content for peripheral blood, bone marrow aspirate, and H&E and IHC of bone marrow biopsies.

eavy chain diseases (HCD) are B-cell neoplasms that only produce monoclonal heavy chain without associated light chains. There are three types involving the three main immunoglobulin classes: gamma, alpha, and mu.

Gamma heavy chain disease presents like lymphoplasmacytic lymphoma in the bone marrow but lacks light chain. The slides demonstrate the presence of a neoplastic plasma cell population. Monoclonal IgG is seen by immunohistochemistry. Clinically, immunofixation will demonstrate IgG without light chain in the blood and/or urine.

This slide shows bone marrow biopsy, CD138 stain. See related content for peripheral blood, bone marrow aspirate, and H&E and IHC of bone marrow biopsies.

Heavy chain diseases (HCD) are B-cell neoplasms that only produce monoclonal heavy chain without associated light chains. There are three types involving the three main immunoglobulin classes: gamma, alpha, and mu.

Gamma heavy chain disease presents like lymphoplasmacytic lymphoma in the bone marrow but lacks light chain. The slides demonstrate the presence of a neoplastic plasma cell population. Monoclonal IgG is seen by immunohistochemistry. Clinically, immunofixation will demonstrate IgG without light chain in the blood and/or urine.

This slide shows bone marrow biopsy, IgG stain. See related content for peripheral blood, bone marrow aspirate, and H&E and IHC of bone marrow biopsies.

Heavy chain diseases (HCD) are B-cell neoplasms that only produce monoclonal heavy chain without associated light chains. There are three types involving the three main immunoglobulin classes: gamma, alpha, and mu.

Gamma heavy chain disease presents like lymphoplasmacytic lymphoma in the bone marrow but lacks light chain. The slides demonstrate the presence of a neoplastic plasma cell population. Monoclonal IgG is seen by immunohistochemistry. Clinically, immunofixation will demonstrate IgG without light chain in the blood and/or urine.

This slide shows bone marrow biopsy, IgM stain. See related content for peripheral blood, bone marrow aspirate, and H&E and IHC of bone marrow biopsies.