Testis, large cell calcifying Sertoli cell tumour

Large cell calcifying Sertoli cell tumours are unusual sex-cord stromal neoplasms of the testis, of uncertain malignant potential. Histologically, they are composed of solid tubules or nests of cells with abundant eosinophilic cytoplasm and prominent nucleoli. As the name suggests, calcifications are common. The young patient age and multifocality suggest an underlying genetic syndrome. Large cell calcifying Sertoli cell tumours are associated with both Carney complex and Peutz-Jeghers syndrome.

Large cell calcifying Sertoli cell tumours are unusual sex-cord stromal neoplasms of the testis, of uncertain malignant potential. Histologically, they are composed of solid tubules or nests of cells with abundant eosinophilic cytoplasm and prominent nucleoli. As the name suggests, calcifications are common. The young patient age and multifocality suggest an underlying genetic syndrome. Large cell calcifying Sertoli cell tumours are associated with both Carney complex and Peutz-Jeghers syndrome.