Soft tissue, granular cell tumour

Granular cell tumours are benign tumours most likely of nerve sheath cells, that can occur at any body site. This is a case showing a well demarcated neoplasm with irregular borders comprised of nests and sheets of monomorphous round cells. Cytoplasm is abundant, granular and amphiphilic. Nuclei are bland, round hyperchromatic with occasional nucleoli; mitotic figures are not conspicuous (1 per 10 HPFs [FD - 0.55 mm]). Stroma consists of thick collagen bundles and entrapped fat cells. Necrosis is not identified. This is an H&E slide.

Granular cell tumours are benign tumours, most likely of nerve sheath cells, that can occur at any body site. This is a case showing a well demarcated neoplasm with irregular borders comprised of nests and sheets of monomorphous round cells. Cytoplasm is abundant, granular and amphiphilic. Nuclei are bland, round hyperchromatic with occasional nucleoli; mitotic figures are not conspicuous (1 per 10 HPFs [FD - 0.55 mm]). Stroma consists of thick collagen bundles and entrapped fat cells. Necrosis is not identified. This slide shows strong diffuse S100 staining.

Granular cell tumours are benign tumours most likely of nerve sheath cells, that can occur at any body site. This is a case showing a well demarcated neoplasm with irregular borders comprised of nests and sheets of monomorphous round cells. Cytoplasm is abundant, granular and amphiphilic. Nuclei are bland, round hyperchromatic with occasional nucleoli; mitotic figures are not conspicuous (1 per 10 HPFs [FD - 0.55 mm]). Stroma consists of thick collagen bundles and entrapped fat cells. Necrosis is not identified. This slide shows strong diffuse nuclear SOX-10 staining.