Details
Biopsy of a pelvic mass
This high‐grade malignant tumour of endometrial stromal derivation is rare. In many cases, it is associated with a distinct chromosomal translocation: t(10;17), resulting in the YWHAE‐FAM22 fusion gene. It is characterized by a mixture of high‐grade round cells and low‐grade spindle cell components. There is a delicate capillary network. Mitoses are numerous. This biopsy represents only a small sampling of the larger mass (see link to a slide from the hysterectomy in the Related Content section).
The tumour is immunohistochemically positive for CD10 and cyclin‐D1, negative for caldesmon (see attached supplementary images in the Related Content section).
Details
Hysterectomy for a pelvic mass.
This high‐grade malignant tumour of endometrial stromal derivation is rare. In many cases, it is associated with a distinct chromosomal translocation: t(10;17), resulting in the YWHAE‐FAM22 fusion gene. It is characterized by a mixture of high‐grade round cells and low‐grade spindle cell components. There is a delicate capillary network. Mitoses are numerous. This biopsy represents only a small sampling of the larger mass (see link to a slide from a diagnostic biopsy in the Related Content section).
The tumour is immunohistochemically positive for CD10 and cyclin‐D1, negative for caldesmon (see attached supplementary images in the Related Content section).