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The patient has a history of Neurofibromatosis Type 1. She developed a retroperitoneal malignant peripheral nerve sheath tumour, which was resected and treated with adjuvant radiation. This specimen represents incidental skin nodules found at the time of surgical evaluation.
Neurofibroma is a tumour of the cells of the nerve sheath that can occur both associated with neurofibromatosis (especially NF1) or sporadically. This example is from a patient with known NF1. The findings are of a well demarcated non-encapsulated cutaneous tumour composed of interlacing fascicles of bland spindled-to-ovoid cells with wavy dark nuclei. There is no mitotic activity or necrosis. The underlying stroma consists of coarse collagen bundles and the overlying epidermis is unremarkable.