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67-year-old woman with chronic headaches. Neuroimaging shows a large right-sided lesion expanding the cortex and white matter accompanied by significant mass effect. Punctate foci of susceptibility artifact (microhemorrhages) were also noted.
Amyloid-beta related angiitis is a vascular condition related to both cerebral amyloid angiopathy (CAA) and primary angiitis of the CNS (PACNS). In CAA, there is deposition of amyloid-beta into the walls of superficial vessels that classically cause lobar and microhemorrhages. PACNS is a primary vasculitis of the CNS. Amyloid-beta related angiitis combines features of both conditions with deposition of amyloid-beta accompanied by an inflammatory vasculitic component. Its appearance on neuroimaging can be misinterpreted as a mass lesion or tumour.