Details
Disease Category
Gender
Age
72 years
Organ System/Discipline
Diagnosis
IgG4-related pachymeningitis
Clinical History
72-year-old man with new-onset seizure. Neuroimaging shows dural-based mass of the left lateral sphenoid wing with mass effect on the frontal and temporal lobes.
Case Discussion
IgG4-related pachymeningitis is a presumed autoimmune disease of the meninges that can occur in isolation or in the setting of systemic IgG4-related disease. Diagnostic histopathologic criteria for IgG4-related pachymeningitis are dense lymphoplasmacytic infiltration of the meninges with more than 10 IgG4-positive cells per high power field. IgG4-related disease is typically responsive to steroids but long term patient outcomes are still lacking.
Image Contributors
Gao, A., Munoz, D.
Cite
Gao, A., Munoz, D. Meninges, IgG4-related pachymeningitis. Digital Laboratory Medicine Library, Dept of Laboratory Medicine & Pathobiology, University of Toronto. Published
. Accessed December 17, 2025. https://dev.dlml.cflabs.ca/image/meninges-igg4-related-pachymeningitis-lmp65234