Details
Termination of pregnancy of male fetus at 22 weeks’ gestational age due to intracranial mass detected on prenatal ultrasound.
Adamantinomatous craniopharyngiomas are benign tumours of the sellar/suprasellar region occurring in children and middle-aged adults classified as WHO grade I. Exceptionally, fetal or neonatal presentations occur. Microscopically, adamantinomatous craniopharyngiomas are characterized by irregularly arranged squamous epithelium bordered by a palisade of columnar epithelium; loosely cohesive aggregates of squamous cells known as stellate reticulum; and nodules of “wet keratin” consisting of anuclear squamous cells. It is associated with CTNNB1 (beta-catenin) mutations. Although benign, prognosis is dependent on size and extent of surgical resection; in congenital cases, tumours are usually large and carry a poor prognosis.