This 70-year-old female had a recent history of resected colorectal cancer. She subsequently developed a 3 cm subcapsular liver mass that was initially suspected to be a metastasis. The mass did not respond to adjuvant chemotherapy, so a diagnosis of hepatocellular carcinoma was favoured. She underwent segment V liver resection.
Case Discussion
Clinical features: Hepatic angiomyolipomas are rare tumours, usually solitary and discovered incidentally.
Histological/molecular features: Variable proportions of epithelioid and spindle cells, adipocytes and thick-walled blood vessels. The classic immunohistochemical profile is co-expression of melanocytic markers and smooth muscle markers. Like other PEComas, hepatic angiomyolipomas harbour mutations in the TSC gene.
MacColl, C. Liver, Angiomyolipoma, SMA. Digital Laboratory Medicine Library, Dept of Laboratory Medicine & Pathobiology, University of Toronto. Published
. Accessed December 17, 2025. https://dev.dlml.cflabs.ca/image/liver-angiomyolipoma-sma-lmp22137
