End-stage liver disease (ESLD), liver explant. History of multifocal hepatocellular carcinoma treated with radio-frequency ablation (RFA). No evidence of residual/recurrent disease.
Case Discussion
Hepatocellular carcinoma (HCC) is the most common primary malignant tumour of the liver in adults, with cirrhosis being a well-established risk factor. While recurrent/residual disease was not suspected based on imaging, sub-centimetre lesions are often missed on radiology. This is a case where a hepatocellular HCC lesion was missed on radiology. These small nodules can pose a significant diagnostic challenge.
This slide shows H&E stain. See related content for trichrome stain.
Yoon, J., Fischer, S. Liver, Residual hepatocellular carcinoma, H&E stain. Digital Laboratory Medicine Library, Dept of Laboratory Medicine & Pathobiology, University of Toronto. Published
. Accessed December 17, 2025. https://dev.dlml.cflabs.ca/image/liver-residual-hepatocellular-carcinoma-he-stain-lmp37500
