Kidney, Cytomegalovirus, H&E stain

Cytomegalovirus is the most common neonatal viral infection. It is a member of the Herpesviridae, double-stranded DNA virus group (HHV-5). Characteristic histologic features include the classic "owl's eye" inclusions, which are readily visible at low power. In the kidney, the affected cells include tubular epithelium, glomerular epithelium, and peritubular capillary endothelial cells. Renal involvement is usually associated with systemic involvement. In this case, the virus resulted in intrauterine death. Uncompromised immunity generally results in benign, self-limiting disease. Long-term sequelae of congenital infections can include hearing impairment, motor deficits, and cognitive impairment.

This slide shows H&E stain. See related content for IHC slide.

See Related Content for references:
1) Naing ZW, et al. Aust N Z J Obstet Gynaecol. 2016 Feb;56(1):9-18.
2) Pass RF, et al. N Engl J Med. 2009 Mar 19;360(12):1191-9.