Pancreas, Solid pseudopapillary tumor

Solid pseudopapillary neoplasm is a tumour commonly found in women with a median age of 26 years old. Patients commonly present with an enlarging or painful abdominal mass, or the tumour is found incidentally through imaging.

Macroscopically, the tumour commonly presents as a large solitary mass that is well circumscribed. It usually consists of a mixture of solid to cystic components, and the cystic components often contain friable and necrotic material. Microscopically, solid pseudopapillary neoplasm consists of solid monomorphic sheets, cords, or nests of polygonal cells with admixed delicate vessels surrounded by hyalinized or myxoid stroma. The cytoplasm is eosinophilic or vacuolated and may contain PAS-positive globules. Nuclei appear round to oval with disperse chromatin. Mitoses are rare. Cystic areas consist of degenerative changes with cholesterol granulomas and foamy histiocytes. Immunohistochemistry shows cytoplasmic staining with CD10 and nuclear staining with B-catenin.