Right breast lumpectomy in a 50-year old patient who noticed skin dimpling. Speculated mass on mammography.
Case Discussion
This is an example of invasive ductal carcinoma (IDC) with prominent tubular features (Nottingham grade I/III). While this may be an added qualifier appropriate in the microscopic description, it is important to distinguish this entity from "tubular carcinoma". While numerous tubular structures are present, "tubular carcinoma" is a low-grade tumour, associated with better prognosis and Rosen’s triad (combination of columnar cell hyperplasia, lobular carcinoma in situ and tubular carcinoma).
This slide shows HER2 stain. See related content for H&E, ER, and PgR stains.
An example of Invasive Tubular Carcinoma can be seen in Case LMP64619 - Breast, Invasive Tubular Carcinoma (link in related content).
Yoon, J. , Bocicariu, A. Breast, Invasive ductal carcinoma, HER2 stain. Digital Laboratory Medicine Library, Dept of Laboratory Medicine & Pathobiology, University of Toronto. Published
. Accessed December 17, 2025. https://dev.dlml.cflabs.ca/image/breast-invasive-ductal-carcinoma-her2-stain-lmp86629
