Details
42 year-old female, history of right breast ductal carcinoma in situ (DCIS) status post lumpectomy with multiple margins less than 1 mm from DCIS. Because she also had contralateral (left breast) invasive ductal carcinoma with nodal involvement she underwent lumpectomy, sentinel lymph node biopsy, and chemotherapy. This specimen is from a re-excision of the right breast DCIS margins.
Chemotherapy related changes can be detected in neoplastic as well as non-neoplastic tissue. Following chemotherapy, there is some evidence that suggests that in situ carcinoma is relatively more resistant to chemotherapy compared to invasive carcinoma.
This was a challenging case where the differences between chemotherapy related changes and residual ductal carcinoma in situ (DCIS) were not entirely clear. This case was reviewed at interdepartemental consensus rounds and was the subject of extended discussion. Ultimately, the consensus was that there was likely some residual DCIS within the lumpectomy specimen > 1 mm from all resection margins. It was determined that the groups of ducts/lobules
Details
42 year-old female, right-breast lumpectomy for ductal carcinoma in-situ (DCIS). The slide is provided for comparison with the post-chemotherapy re-excision specimen (see Related Content).
This slide shows the lumpectomy for ductal carcinoma in-situ (DCIS) and is provided for comparison with the post-chemotherapy re-excision (see Related Content).
Chemotherapy related changes can be detected in neoplastic as well as non-neoplastic tissue. Following chemotherapy, there is some evidence that suggests that in situ carcinoma is relatively more resistant to chemotherapy compared to invasive carcinoma.